Supplemental Figure 1: The S147G mutation does not lead to increased RII subunits - its main effect is through lack of binding to the catalytic subunit (Ca).
Ratio of R1a Expression to Type II Subunits Expression
R1alpha exp (R2alpha + R2beta exp)
±SE
2.50
NS
2.00
Met1Val, Ser9Asn, Arg74Cys, Arg146Ser, Ser147Cys, Asp183Tyr
1.50
1.00
Ala213Asp, Gly289Trp, Exon 3 skip
0.50
*
T
I
0.00
Abs R2b Exp < WT Abs R2b Exp
Abs R2b Exp > WT Abs R2b Exp
WT