IMAGES IN UROLOGY
Images - Oncocytic adrenocortical carcinoma: A rare tumor variant
Ian Lehr; Charlie Gillis; Chris French, MD; Andrea Simmonds, MD; Michael Organ, MD
Memorial University, St. John’s, NL, Canada
Cite as: Can Urol Assoc J 2020;14(1):E45. http://dx.doi.org/10.5489/cuaj.5967
Published online June 17, 2019
A drenocortical carcinoma (ACC) is an uncommon malignancy, with an incidence of 1-2 per million per year, and has three main histological variants: oncocytic, myxoid, and sarcomotoid.1 Oncocytic variants are mainly composed of eosinophilic cells with focal nuclear atypia and an abundance of mitochondria.2
The malignant potential of oncocytic adrenal tumors can be predicted using the Lin-Weiss-Bisceglia (LWB) criteria.3 First, this proposes that oncocytic tumors share common characteristics, known as the definitional criteria (predomin- antly cells with eosinophilic granular cytoplasm, high nucle- ar grade, and diffuse architectural pattern), which are not deterministic for malignancy but used instead for classifica- tion. For distinguishing malignant potential, the major cri- teria include a mitotic rate of >5 mitoses per 50 high power
fields (hpfs), atypical mitoses, or venous invasion. The minor criteria include large size (>10 cm diameter and/or >200 g), necrosis, capsular invasion, or sinusoidal invasion. The pres- ence of any major criteria stratifies a mass as malignant; the presence of any minor criteria suggests a tumor of borderline or uncertain malignant potential. If no features are present, the mass is likely to be benign (oncocytoma).3
Fig. 1 demonstrates the case of a 55-year-old woman with a large left adrenal mass found on computed tomography scan (13.3 x 7.7 x 10.8 cm). Pathology reported an adrenal mass weighing 900 g and measuring 16.5 cm x 15.6 cm x 5.4 cm. The mass had a lobulated, tan appearance with focal areas of hemorrhage and necrosis. The tumor cells were noted to be calretinin-positive and chromogranin-negative, supporting a cortical lesion and ruling out the diagnosis of a pheochromocytoma. The tumor cells were noted to be sheet-like and highly eosinophilic, with greater than 20 mitoses per 50 hpfs and occasional atypical mitoses. This supported the diagnosis of an ACC, oncocytic subtype. Using the Lin-Weiss-Bisceglia criteria for classification of oncocytic adrenal neoplasms, this mass met two major criteria (mitotic rate of >5 per 50 hpfs and atypical mitoses) and two minor criteria (large size >10 cm and/or 200 g and necrosis), indi- cating that it was a malignant oncocytic ACC.
Competing interests: The authors report no competing personal or financial interests related to this work.
This paper has been peer-reviewed.
References
1. Allolio B, Fassnacht M. Clinical review: Adrenocortical carcinoma: Clinical update. J Clin Endocrinol Metab 2006;91:2027-37. https://doi.org/10.1210/jc.2005-2639
2. Erlandson R, Reuter V. Oncocytic adrenal cortical adenoma. Ultrastruct Patho/ 1991;15:539-47. https:// doi.org/10.3109/01913129109016261
3. Bisceglia M, Ludovico O, Di Mattia A, et al. Adrenocortical oncocytic tumors: Report of 10 cases and review of the literature. Int J Surg Pathol 2004; 12:231-43. https://doi.org/10.1177/106689690401200304
Correspondence: Mr. lan Lehr, Memorial University, St. John’s, NL, Canada; inl521@mun.ca