Supplement Figure 2 related to Figure 4.
A
x-Axis Cell Line Set
ACC NCI plus Surgical
x-Axis Data Type
mda:Signatures, Miscellaneous data
Identifier
ADS
y-Axis Cell Line Set
ACC NCI plus Surgical
y-Axis Data Type
xsq: RNA-seq Expression (log2 FPKM+1)
Identifier
NR5A1
Univariate Analysis / Plot Data NR5A1 (xsq) vs. ADS (mda) Pearson correlation (r)=0.68, p-value=0.03
· CU-ACC1
· CU-ACC2
· H295R
· SW-13
· ACC surgical
CU-ACC1
NR5A1 (xsq, ACC NCI plus Surgical)
7.5
H295R
31
38
33
30
5.0
34
37
CU-ACC2
2.5
SW-13
0.0
-1.0
-0.5
0.0
0.5
1.0
1.5
ADS (mda, ACC NCI plus Surgical)
B
x-Axis Cell Line Set
ACC NCI plus Surgical
x-Axis Data Type
xsq: RNA-seq Expression (log2 FPKM+1)
Identifier
DLK1
y-Axis Cell Line Set
ACC NCI plus Surgical
y-Axis Data Type
xsq: RNA-seq Expression (log2 FPKM+1)
Identifier
IGF2
Univariate Analysis / Plot Data IGF2 (xsq) vs. DLK1 (xsq) Pearson correlation (r)=0.92, p-value=0.00013
12.5
CU-ACC1
31
IGF2 (xsq, ACC NCI plus Surgical)
33
10
34
30
38
37
7.5
H295R
5
CU-ACC2
2.5
0
SW-13
0
5
10
DLK1 (xsq, ACC NCI plus Surgical)
(A) Correlation between the ADS score and the Nuclear Receptor Subfamily 5, Group A, Member 1 NRSA1, which also referred to as Steroidogenic Factor-1 (SF1).
(B) Overexpression of IGF2 in ACC cell lines and tumor samples and correlation with the expression of the surface receptor gene DLK1.