Selective Use of Steroid Replacement After Adrenalectomy
Lessons From 331 Consecutive Cases
Wen T. Shen, MD; James Lee, MD; Electron Kebebew, MD; Orlo H. Clark, MD; Quan-Yang Duh, MD
Hypothesis: Only selected patients require steroid re- placement therapy following adrenalectomy.
Design: Retrospective review.
Settings: University tertiary care center and veterans’ hospital.
Patients: A total of 331 patients who underwent adre- nalectomy by 1 surgeon (Q .- Y.D.) between April 1, 1993, and August 31, 2005.
Interventions: Laparoscopic, open, and hand-assisted adrenalectomy. Steroid replacement therapy was admin- istered using a standardized hydrocortisone taper pro- tocol.
Main Outcome Measures: Indications for adrenal- ectomy, operative approach, requirement for postopera- tive steroid replacement, and episodes of acute adreno- cortical insufficiency.
Results: Of the 331 adrenalectomies, 304 were laparo- scopic, 23 were open, and 4 were hand assisted. There were 299 unilateral adrenalectomies and 32 bilateral ad- renalectomies performed. Fifty-seven (17%) of the 331 patients required steroid replacement after adrenalec-
tomy. Of the 57 patients requiring steroid replacement, 52 had Cushing syndrome and 5 had bilateral pheochro- mocytomas. The 52 patients with Cushing syndrome in- cluded 16 with pituitary tumors who had failed pitu- itary resection and/or medical therapy, 14 with unilateral adrenal adenomas, 9 with ectopic corticotropin- secreting tumors who had failed resection and/or medi- cal therapy, 7 with incidentalomas and subclinical Cush- ing syndrome, 4 with macronodular hyperplasia, and 2 with adrenocortical carcinoma. No patients undergoing unilateral adrenalectomy for non-Cushing adrenal dis- ease required steroid replacement. Four (7%) of the 57 patients receiving steroid replacement had episodes of acute adrenocortical insufficiency following operation and required increased steroid supplementation. There were no cases of acute adrenocortical insufficiency in the 274 patients who did not receive steroid replacement.
Conclusions: Steroid replacement therapy after adre- nalectomy should be reserved for patients with Cushing syndrome (overt or subclinical) and patients undergo- ing bilateral adrenalectomy. Patients undergoing adre- nalectomy for unilateral non-Cushing adrenal tumors do not require postoperative steroid replacement.
Arch Surg. 2006;141:771-776
Author Affiliations: Department of Surgery, University of California, San Francisco.
T HE PRACTICE OF PROVIDING perioperative glucocorti- coid replacement therapy to prevent adrenal insuffi- ciency in patients receiv- ing steroids for inflammatory conditions is well established.1,2 Since the early 1950s when the first articles3,4 describing the dan- gers of postoperative adrenal insuffi- ciency in steroid-dependent patients were published, the standard of care has been to treat these patients with physiologic or supraphysiologic doses of steroids dur- ing the perioperative period. Within the past 2 decades, there has been consider- able debate regarding the amount of ste-
roid replacement needed to provide ad- equate coverage for perioperative stress; the concept and practice of administer- ing supraphysiologic, or “stress-dose,” ste- roids has been called into question by sev- eral investigators,5-8 and new guidelines for steroid-dependent patients undergoing op- erations have been proposed and used.5-8
Another population of patients who may require perioperative steroid supplementa- tion consists of patients undergoing adre- nalectomy for the spectrum of primary ad- renal tumors or, less commonly, adrenal metastases or extra-adrenal hypersecre- tory conditions. However, few published guidelines exist for identifying precisely
| Characteristic | Patients Requiring Postoperative Steroids (n = 57) | Patients Not Requiring Postoperative Steroids (n = 274) |
|---|---|---|
| Episodes of adrenal insufficiency, No. | 4 | 0* |
| Infectious complications, No. | 4 | 0* |
| Length of hospital stay, mean ± SEM, d | 2.6 ± 0.3 | 1.5 ±0.1* |
*P <. 05.
which patients undergoing adrenalectomy require peri- operative steroids. Not all patients undergoing adrenalec- tomy are at risk for postoperative adrenal insufficiency, and unnecessary steroid administration is associated with a host of deleterious effects, including poor wound healing, blood glucose level abnormalities, and other metabolic derange- ments. We therefore reviewed our experience with pa- tients who underwent adrenalectomy during the past de- cade, with the goal of identifying which patients required perioperative steroid replacement. We aimed to provide ra- tional guidelines for the administration of steroids in pa- tients undergoing adrenalectomy and to highlight the sub- groups of patients who are at highest risk for postoperative adrenal insufficiency.
METHODS
We reviewed the medical records of all of the patients who un- derwent adrenalectomy by 1 surgeon (Q .- Y.D.) between April 1, 1993, and August 31, 2005. Patients who underwent open, laparoscopic, or hand-assisted adrenalectomy were included. The clinical presentation and indications for operation were re- corded for each patient. All of the operations were performed at the University of California, San Francisco, Medical Center, the San Francisco Veterans Affairs Medical Center, the Uni- versity of California, San Francisco/Mt Zion Medical Center, or the San Francisco General Hospital.
All of the patients requiring postoperative steroid supple- mentation were identified, and their indications for and dura- tion of steroid therapy were recorded. Steroid supplementa- tion was administered using a standardized protocol established in conjunction with medical endocrinologists at our institu- tion. Postoperative complications were noted, including all epi- sodes of adrenal insufficiency requiring additional steroid supple- mentation and any complications related to hypercortisolism (including wound infections and other infectious complica- tions). Episodes of adrenal insufficiency following operation were documented by either serum or urinary testing in pa- tients with symptoms or signs of hypocortisolism. The dura- tion of hospitalization was recorded. In our practice, all of the patients are seen for follow-up by the surgeon between 2 and 4 weeks after operation. If there are no persistent postopera- tive problems, subsequent follow-up is with the patient’s en- docrinologist or primary care physician. Episodes of delayed adrenal insufficiency, tumor recurrence, or other long-term com- plications either were reported directly to the surgeon or were identified during record reviews and follow-up telephone calls to referring physicians for this study.
RESULTS
Between April 1, 1993, and August 31, 2005, 331 pa- tients underwent adrenalectomy by 1 surgeon (Q .- Y.D.) at the University of California, San Francisco, or one of its affiliated institutions. Of these 331 patients, 304 un- derwent laparoscopic adrenalectomy, 23 underwent open adrenalectomy, and 4 underwent hand-assisted laparo- scopic adrenalectomy. Of the 23 open adrenalectomies, 4 were initially attempted laparoscopically but were con- verted to open adrenalectomy because of difficult dis- section or intraoperative findings that may have been in- dicative of malignancy. The indications for operation for the 331 patients included aldosteronomas in 108 pa- tients, pheochromocytomas in 71 patients (including bi- lateral pheochromocytomas in 5 patients), Cushing syn- drome in 52 patients, nonfunctioning cortical adenomas in 34 patients, isolated adrenal metastases in 29 pa- tients, adrenocortical carcinoma (not causing Cushing syndrome) in 5 patients, and a virilizing adrenal tumor in 1 patient. The remaining 31 patients who underwent adrenalectomy during this period had other types of uni- lateral nonfunctioning adrenal tumors (including my- elolipomas, adrenal cysts, and adrenal hemorrhages).
Fifty-seven (17%) of 331 patients required steroid re- placement following adrenalectomy; the remaining 274 patients did not require or receive any form of postop- erative steroid supplementation. The 57 patients receiv- ing steroids included 52 patients with Cushing syn- drome and 5 with bilateral pheochromocytomas who underwent bilateral adrenalectomies. All of the 52 pa- tients with Cushing syndrome were diagnosed preop- eratively by biochemical testing either because of clini- cal features of hypercortisolism or as part of the routine workup of an incidentally discovered adrenal mass. The cause of glucocorticoid excess in the 52 patients with Cushing syndrome included functioning pituitary tu- mors in 16 patients who had failed pituitary resection and/or medical therapy; functioning unilateral adrenal cortical adenomas in 14 patients; ectopic corticotropin- secreting tumors in 9 patients who had failed resection and/or medical therapy; subclinical Cushing syndrome in 7 patients who had been diagnosed during biochemi- cal workup of an incidentaloma; bilateral adrenal mac- ronodular hyperplasia in 4 patients; and functioning ad- renocortical carcinoma in 2 patients. The 5 patients with bilateral pheochromocytomas included 3 with multiple endocrine neoplasia type 2A or 2B, 1 with Osler-Weber- Rendu syndrome, and 1 with neurofibromatosis.
A comparison of postoperative complications in pa- tients who received steroid supplementation and pa- tients who did not receive steroids is provided in Table 1. The 57 patients who underwent steroid replacement in- cluded 4 who required additional steroid therapy be- cause of signs and symptoms of addisonian crisis. Infec- tious complications developed in 4 patients undergoing steroid replacement therapy: 2 patients developed wound infections in trocar sites, necessitating bedside incision and drainage; 1 patient developed a subphrenic abscess requiring drainage by interventional radiology; and 1 pa- tient developed severe postoperative pneumonia and a
| Age, y/Sex | Diagnosis | Operation | Time After Operation | Symptoms of Adrenal Insufficiency | Outcome |
|---|---|---|---|---|---|
| 66/F | Cushing syndrome, ectopic corticotropin-secreting tumor | Laparoscopic bilateral adrenalectomy | 2 d | Fever, nausea, failure to thrive | Improved, 5 d in hospital |
| 51/F | Cushing syndrome, pituitary adenoma | Laparoscopic bilateral adrenalectomy | 3 d | Hypotension, shock requiring intensive care unit care | Improved, 9 d in hospital |
| 43/F | Subclinical Cushing syndrome, incidentaloma | Laparoscopic right adrenalectomy | 1 y | Fatigue, nausea, dizziness during steroid taper | Improved, but recurrent episode during treatment for gallstones 1 y later |
| 40/M | Cushing syndrome, bilateral macronodular hyperplasia | Laparoscopic bilateral adrenalectomy | 2 y | Diarrhea, nausea, vomiting | Improved, no repeat hospitalization |
urinary tract infection with subsequent extended hospi- talization. In comparison, of the 274 patients who did not receive perioperative steroid replacement, only 1 de- veloped an infectious complication after adrenalectomy (P <. 001). Of the patients who underwent steroid re- placement, 1 with adrenocortical carcinoma developed local recurrence requiring reoperation. One patient with multiple endocrine neoplasia type 2B and bilateral pheo- chromocytomas developed local recurrence requiring re- operation and died several months later of metastatic med- ullary thyroid carcinoma. There was 1 postoperative death in a patient with an ectopic corticotropin-secreting tu- mor who underwent emergent operation after develop- ing acute multisystem failure despite aggressive medi- cal therapy; this patient developed uncontrollable postoperative bleeding and died 1 day after operation.
The clinical features of the 4 patients who developed postoperative adrenal insufficiency despite glucocorticoid replacement are listed in Table 2. These 4 patients who required additional steroid supplementation included 2 patients who developed hypocortisolism in the immedi- ate postoperative period and 2 patients who presented sev- eral months to years after their operations. The 2 imme- diate cases of addisonian crisis included 1 patient with pituitary Cushing syndrome who became critically hypo- tensive and required transfer to the intensive care unit on postoperative day 3 as well as 1 patient with an ectopic corticotropin-secreting tumor who developed fever, nau- sea, and failure to thrive on postoperative day 2. Both of these patients improved after additional supplemental steroid therapy. The 2 cases of delayed addisonian crisis included 1 patient with macronodular hyperplasia who had severe gastrointestinal distress 2 years after his bilat- eral adrenalectomy as well as 1 patient with subclinical Cushing syndrome who became acutely fatigued, nause- ated, and dizzy while attempting to wean off of steroids 1 year after her adrenalectomy. These 2 patients with de- layed symptoms of hypocortisolism showed improvement after additional supplemental steroid therapy; the patient with subclinical Cushing syndrome had another episode of addisonian crisis while being treated for cholecystitis 2 years after her adrenalectomy and required increased doses of steroids during this period.
The mean±SEM length of hospitalization after adre- nalectomy in the 57 patients who required periopera-
tive steroid supplementation was 2.6±0.3 days. The mean±SEM length of postoperative hospitalization for the 274 patients who did not require steroid supplemen- tation was 1.5±0.1 days (P =. 002).
COMMENT
In this study, we reviewed the clinical presentations and postoperative outcomes of 331 consecutive patients who underwent adrenalectomy during a 12-year period, and we identified factors that determined the requirement for peri- operative steroid supplementation. The results of this in- vestigation suggest that only patients with preoperatively diagnosed Cushing syndrome (either overt or subclini- cal) and patients undergoing bilateral adrenalectomy re- quire perioperative steroid supplementation. In addition, patients receiving steroids for other medical conditions (eg, asthma, inflammatory bowel disease, rheumatoid arthri- tis) need to receive steroid coverage after adrenalectomy as they would with any operation. Patients undergoing uni- lateral adrenalectomy for non-Cushing adrenal tumors do not require perioperative steroid supplementation. The only cases of postoperative addisonian crisis that we encoun- tered during this 12-year study period were in patients with Cushing syndrome. Overall, 4 (1%) of 331 patients under- going adrenalectomy at our institution had an episode of postoperative hypocortisolism; this result is similar to that reported in other single-institution studies9 of patients un- dergoing adrenalectomy. We also found that patients re- quiring perioperative steroid supplementation are at higher risk for postoperative infectious complications and have a significantly longer hospital stay than patients who do not require steroids.
In our practice, perioperative steroid replacement is administered according to a standardized protocol that was established with assistance from the medical endo- crinologists at our institution. The protocol calls for 100 mg of intravenous hydrocortisone to be given prior to operation, followed by 100 mg of intravenous hydrocor- tisone every 8 hours for 1 day or an equivalent daily dose of oral prednisone, then a subsequent rapid 3-day taper to a maintenance dose of 25 mg twice daily of intrave- nous hydrocortisone or an equivalent dose of oral pred-
nisone until the patient is seen in follow-up. Patients who undergo bilateral adrenalectomy will require lifelong ste- roid supplementation whereas those with Cushing syn- drome who undergo unilateral adrenalectomy can usu- ally be tapered off of all steroids within 6 months to 1 year.10-14 In our practice, the referring endocrinologist or primary care physician determines the final tapering regi- men for patients weaning off of steroids; all of the pa- tients undergo repeat biochemical testing to confirm the integrity of the hypothalamic-pituitary axis prior to dis- continuing steroid therapy. It is important to note that patients with Cushing syndrome may develop signs and symptoms of hypocortisolism months and even years af- ter their adrenalectomy; 2 of the 4 patients with postop- erative adrenal insufficiency in this study group pre- sented within 1 to 2 years after operation.
Patients with subclinical Cushing syndrome repre- sent an interesting subgroup of our study population. Subclinical Cushing syndrome is defined by autono- mous secretion of glucocorticoids without overt clinical manifestations of Cushing syndrome. We identified 7 pa- tients with this condition; these patients had inciden- tally discovered adrenal masses and no clinical features of hypercortisolism but were found to have elevated cor- tisol secretion on biochemical workup of their inciden- talomas. These patients with subclinical Cushing syn- drome are at risk for postoperative addisonian crisis and should receive steroid supplementation; 1 patient with subclinical Cushing syndrome in our study had 2 epi- sodes of postoperative hypocortisolism despite steroid re- placement. Other investigators15,16 have reported cases of fatal adrenal insufficiency in patients with subclinical Cushing syndrome who did not receive glucocorticoid supplementation after adrenalectomy. As the frequency of incidentalomas continues to rise in conjunction with the increased use of abdominal computed tomographic scans and magnetic resonance images, it is of para- mount importance that clinicians be aware of the exis- tence of subclinical Cushing syndrome.17,18 Up to 20% of patients with incidentally discovered adrenal masses will have evidence of glucocorticoid excess on biochemi- cal testing.17,18 All patients with an incidentally discov- ered adrenal mass should undergo biochemical testing to evaluate for hypersecretion of glucocorticoids and cat- echolamines, even if the patients are asymptomatic. For workup of hypercortisolism, our preference is to per- form an overnight low-dose dexamethasone suppres- sion test; in addition, we usually obtain a 24-hour uri- nary cortisol measurement since all of the patients undergo urinary testing for fractionated metanephrines and cat- echolamines to rule out pheochromocytoma.19
In conclusion, our review of 331 patients who under- went adrenalectomy during the past 12 years suggests that only patients with overt or subclinical Cushing syn- drome and patients undergoing bilateral adrenalectomy require perioperative steroid supplementation. Patients undergoing unilateral adrenalectomy for non-Cushing ad- renal tumors do not require steroid replacement. Pa- tients who receive steroids for other medical conditions should continue their steroid regimen after adrenalec- tomy as they would after any other abdominal opera- tion; the decision to give stress-dose steroids to these pa-
tients is dependent on patient history, extent of operation, and clinician judgment.
Accepted for Publication: April 13, 2006.
Correspondence: Quan-Yang Duh, MD, San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121 (quan-yang.duh@med.va.gov). Previous Presentation: This paper was presented at the 77th Annual Meeting of the Pacific Coast Surgical Asso- ciation; February 19, 2006; San Francisco, Calif; and is published after peer review and revision. The discus- sions that follow this article are based on the originally submitted manuscript and not the revised manuscript.
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DISCUSSION
Brett Sheppard, MD, Portland, Ore: This is a well-presented body of work that details a very extensive and rich experience in the surgical care of adrenal disease. These are outcomes that we can all be proud of and, as such, will provide us with a bench- mark for adrenal surgery to refer to in years to come.
The authors have made several important points which de- serve reemphasis. First, superphysiologic or so-called stress doses of perioperative steroids are required only in a limited num- ber of patient populations. In 1997 at our institution, Dr Loriaux previously reported in Surgery a randomized, double-blind study looking at steroid replacement in patients already on steroids undergoing surgery. He reported patients only required their normal dose of steroids around surgery and not supraphysi- ologic doses.
Today, Dr Duh has shown us that only 17% of patients un- dergoing adrenalectomy will require steroid replacement and that this population is confined to patients with depression of their hypothalamic-pituitary-adrenal axis from Cushing’s syn- drome or those patients undergoing bilateral adrenalectomy. These data and other studies should prompt all of us to reex- amine the use of perioperative supraphysiologic doses of ste- roid replacement.
Second, the authors draw attention to the importance of sub- clinical Cushing’s syndrome. As they point out, this diagnosis is becoming increasingly more important as we discover more incidentalomas with our imaging. In some series, the diagno- sis of subclinical Cushing’s syndrome is as high as 10%. When found early, patients may be spared the full expression of Cushing’s syndrome. The authors describe the gold standard biochemical testing for this disease, but I am wondering if they have any experience with the use of midnight salivary corti- sols and what utility this may have in the future.
Using a standardized protocol for steroid replacement, the authors have minimized the incidence of early addisonian cri- sis. However, I would like to ask if they have noted any differ- ence in the response to their protocol or the need to deviate from their protocol in patients undergoing bilateral adrenal- ectomy for pheochromocytoma vs those undergoing the same operation for Cushing’s syndrome.
Also, although the number of open cases was low, reflect- ing the current practice, was there any difference in the pro- tocol administration between those patients undergoing an open adrenalectomy vs a laparoscopic adrenalectomy? Patients with florid Cushing’s syndrome may also develop a prompt diure- sis following a surgical cure. Do you have a protocol in place to address the fluid and electrolyte flux?
Drawing on our own experience in some 39 patients un- dergoing bilateral adrenalectomy for Cushing’s syndrome, we found some patients could not be successfully weaned off to maintenance doses of steroids. We postulated this might be linked to the time and duration of disease. That is, these pa- tients became accustomed to the loss of diurnal variation and require consistently higher levels of steroids. I am wondering if you have any experience with this and what your approach to this problem is.
In addition, in our patient population, patients self-report about a 45% incidence of 1 or more addisonian crises more than 1 year out from their bilateral adrenalectomy. We are unsure what this represents, whether it is related to steroid with- drawal or other causes. However, I am beginning to believe that our patients require long-term support to reap the full benefit from surgery. I am wondering what the approach at UCSF [Uni- versity of California, San Francisco] is to this.
One final question. Patients with Cushing’s syndrome of- ten present very unique surgical challenges. They often will have BMIs [body mass indices] greater than 35 with central depo- sition of their fat and have other significant comorbidities. I am hoping you may share with us some clinical protocols you may have developed that have led to such good outcomes.
L. William Traverso, MD, Seattle, Wash: I would like to ask you [Dr Shen] and Dr Duh one additional twist to this. I have a patient in the hospital now who 10 years ago had a 5-cm adrenal cortisol-secreting tumor resected, and then a few months
ago, she had a 22-unit bleed from a gut stromal tumor cen- tered around the ampulla of Vater. Wednesday, I took that out with a Whipple procedure and now I can’t keep her potassium up. Could you tell me what to do?
Philip I. Haigh, MD, Los Angeles, Calif: I just wanted to ask how the authors monitor these patients postoperatively, and it really relates to that 1 patient with subclinical Cushing’s syn- drome. Only 5% of the Cushing’s patients with much more se- vere disease developed problems, so finding this 1 patient with subclinical Cushing’s disease causing such prolonged adrenal insufficiency is fascinating. I am just wondering if it perhaps could have been an iatrogenic problem because of excess ex- ogenous steroids given maybe for a longer time than was an- ticipated.
Rodney F. Pommier, MD, Portland: The adrenals get more metastases per gram of tissue than any other organ. We see ad- renal insufficiency in our surgical oncology patients present- ing with what appears to be a unilateral adrenal metastasis fairly often, presumably because the other gland is also affected. You did not, so I thought that was very interesting. Either you have carefully selected a group of patients with true unilateral ad- renal metastases or the patients have aggressive tumors and are dying of other metastases before insufficiency occurs in the other adrenal gland. My questions are, what were the most common primary tumor histologies in these patients who had an adre- nalectomy for a metastasis, and what was their median sur- vival after the adrenalectomy?
Dr Duh: Midnight salivary cortisol levels are used by some people to diagnose Cushing’s. We have not used it in our in- stitution. It is supposed to be a good test, but we don’t have any experience with it.
Do we use a different protocol or do we deviate from the protocol for those who undergo bilateral adrenalectomy for pheo- chromocytomas or for those who undergo open operations? No. We try to use the same protocol so people don’t get confused. Of our 2 patients who had adrenal insufficiency immediately postoperatively, neither had pheochromocytoma. None of our open adrenal patients had adrenal insufficiency with this pro- tocol. This means supraphysiologic doses beyond what we have in this protocol that you may expect are needed for patients who undergo open operation probably aren’t necessary. So, I think our protocol works well in general. But, we need to keep in mind that despite using this protocol, we had 2 patients who had adrenal insufficiency on postoperative day 2 and day 3, so some patients may need more steroid or may need to be ta- pered more slowly.
Postoperative diuresis is a very interesting question. A fre- quently made mistake is to pull the Foley catheter immedi- ately after the operation thinking that a simple laparoscopic adrenalectomy is like a laparoscopic cholecystectomy. These patients all have significant diuresis, not just the Cushing’s patients. Because we operate with the patient in the lateral po- sition, they tend to retain a lot of fluid, and when they are turned supine postoperatively, they diurese. Cushing’s pa- tients do diurese more, and we replace the fluid as needed. Since most patients are eating by the next day, fluid replace- ment is not a problem.
Difficulty in weaning patients off steroid is the most impor- tant issue. We begin weaning Cushing’s patients several months postoperatively, and this is usually done by the endocrinolo- gist. There is a very good study by Gerry Dougherty that showed the suppression of the pituitary-adrenal axis to last a median of 15 months. That is, more than a year after a unilateral ad- renalectomy, half of the Cushing’s patients still have trouble weaning off their steroids.
How do we support these patients? I think it is very impor- tant that these patients have a good endocrinologist and that they work very closely together. We have some excellent ad-
renal endocrinologists at UC [University of California], and it is essentially their responsibility to follow and wean these pa- tients. Some may be difficult to wean. For example, 1 of the 2 patients who had delayed adrenal insufficiency was a young pa- tient who had subclinical Cushing’s and couldn’t get preg- nant. We resected her 2-cm adrenal adenoma, but she could not be weaned for a couple of years. She got pregnant and dur- ing her pregnancy required more steroids. After her preg- nancy, she had cholecystitis and needed a laparoscopic chole- cystectomy. Again, she needed more steroids. She is now 4 to 5 years after adrenalectomy and is finally weaned off steroids. But, I am not sure that if she were to get diverticulitis or other problems, that she may again require steroids.
We do manage patients with Cushing’s differently. They are the only patients to get perioperative antibiotics. We do not give perioperative antibiotics to other patients for adrenalectomy, only for those with Cushing’s. Despite perioperative antibiot- ics, 4 Cushing’s patients had infectious complications whereas those without Cushing’s got no antibiotics and had no infec- tions.
Dr Traverso, I don’t know about the connection between adrenal insufficiency and GI [gastrointestinal] stromal tu- mors, but if I think the patient is addisonian, I would give the
patient steroids. Although we are concerned about the com- plications of chronic steroid use, in situations like this, the risk of not giving the steroid is higher than the risk of giving a short course of steroids. To confirm the diagnosis, the endocrinolo- gists like us to draw a cortisol level before treating the patient. You can also use dexamethasone, which does not cross-react in the assay for cortisol, so they can still under go a Cortrosyn stimulation test.
For Dr Haigh, how do we monitor these patients? Again, a good endocrinology colleague is very important. We talk to these patients before their operation so that they know they may have to deal with long-term issues related to adrenal insufficiency.
Dr Pommier brought up the subgroup of patients with ad- renal metastasis. We had 29 patients in whom we resected ad- renal metastasis. The adrenal gland is one of the most com- mon sites for metastasis, but isolated adrenal metastases are quite rare. These can be resected safely. Surprisingly enough, we have not seen any local recurrence from laparoscopic re- section of adrenal metastasis. Dr Kebebew presented our re- sults at the Pacific Coast Surgical a few years ago. About a third of the patients subsequently had systemic recurrences, but two thirds had a long survival after resection of isolated adrenal metastases.