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precision_medicine_and_biomarker_development

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Precision Medicine and Biomarker Development

ACC overview

Precision oncology in ACC is most coherent when biomarker work is split into tissue and genomic classifiers, circulating or liquid-biopsy markers, steroid and functional biomarkers, and the newer multi-omics stratification literature.123

Research Map

Tissue and Genomic Biomarkers in ACC

These studies focus on tumor-based biomarkers such as copy-number profiles, methylation assays, transcriptomic markers, and tissue protein expression.123

Grouped note: Tissue and Genomic Biomarkers in ACC

Circulating Biomarkers and Liquid Biopsy in ACC

This cluster covers serum markers, circulating microRNAs, circulating tumor cells, and ctDNA approaches meant to make ACC monitoring less invasive.123

Grouped note: Circulating Biomarkers and Liquid Biopsy in ACC

Steroid Metabolomics and Therapeutic Biomarkers in ACC

These papers cover urine steroid metabolomics, steroid sulfation, and biomarkers linked to mitotane or platinum sensitivity.123

Grouped note: Steroid Metabolomics and Therapeutic Biomarkers in ACC

Molecular Classification and Computational Signatures in ACC

This note groups machine-learning, radiomic, multi-omics, and computational prognostic signatures that aim to stratify ACC beyond conventional pathology.123

Grouped note: Molecular Classification and Computational Signatures in ACC

How to Read This Literature

The grouped notes below separate markers that help diagnose or classify tumors from those intended to track residual disease or predict treatment response.123

See Also

References

Footnotes

  1. Telomerase activity as an indicator of potentially malignant adrenal tumors.. Cancer. 1998. PMID: 9708944. Local full text: 9708944.md ↩ ↩2 ↩3 ↩4 ↩5 ↩6

  2. Telomerase activity in benign and malignant adrenal tumors.. Exp Clin Endocrinol Diabetes. 1999. PMID: 10433067. Local full text: 10433067.md ↩ ↩2 ↩3 ↩4 ↩5 ↩6

  3. Expression of the angiogenesis markers vascular endothelial growth factor-A, thrombospondin-1, and platelet-derived endothelial cell growth factor in human sporadic adrenocortical tumors: correlation with genotypic alterations.. J Clin Endocrinol Metab. 2000. PMID: 11134136. Local full text: 11134136.md ↩ ↩2 ↩3 ↩4 ↩5 ↩6

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